Professional harmonica is a harmonica used for professional playing. The preferred choice of harmonicas for professional playing is the chromatic harmonica. They are very many brands that make professional harmonica. The chromatic harmonica has a range of notes unlike any other harmonicas since it is a 4-octave harmonica. It throws out more challenges for a player unlike the diatonic harmonica. Chromatic harmonicas add on a little of different timbres and effects like tremolos. The best professional harmonica is a type of a chromatic harmonica.